Immune substances may help antibody-based drugs fight cancer

A new study suggests that antibody-based cancer drugs might help patients more if they are given with substances that stimulate the immune system.

This new study is the first to indicate that the drug trastuzumab, also known as Herceptin, may work better when it is followed by injections of interleukin (IL) 2 or IL-12. Both substances trigger the activity of immune cells known as natural killer (NK) cells.

The research, by scientists at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, is published in the Jan. 1 issue of the journal Cancer Research.

The drug trastuzumab consists of an antibody that targets the protein HER2, which is present on cancer cells of many breast tumors. NK cells are the body’s first line of defense against many infections, and they also attack tumor cells.

NK cells rush into action when they encounter bacteria or other foreign agents in the body that are coated with antibodies, large proteins released by immune cells in response to the presence of foreign material in the body.

Trastuzumab is used to treat advanced breast cancer cases that over-produce the HER2 protein. The drug coats the tumor cells with antibodies, but it is unclear exactly what happens next.

Presently, researchers believe that when the trastuzumab antibodies join with the HER2 protein, they trigger changes within the tumor cells that cause the cells to die or to grow more slowly. In this scenario, the immune system plays a relatively minor role in slowing the tumor’s growth.

“But our results show that the immune system really can play an important role in this therapy and that the outcome of patients treated with antibody-based drugs might be improved by activating the patient’s immune system with agents such as IL-12,” says principal investigator William E. Carson, III, associate professor of surgery and director for clinical research at the OSU Comprehensive Cancer Center.

First author Julie M. Roda, a graduate research associate in Carson ’s laboratory, explained why this is so.

“The findings suggest that using trastuzumab and the IL-12 together makes the body think an infection is under way, and this activates cells of the immune system to eliminate tumor cells in the same way they would eliminate an infection,” says Roda.

The investigators found that the combination of antibody-coated cells and IL-2 or IL-12 causes the NK cells to release substances that attract more potent immune cells – mainly killer T cells – thereby trigging a larger and more effective immune response against the tumor.

“Trastuzumab was not designed to mimic an infectious condition, but we think that’s exactly what is happening,” Roda says.

Carson, Roda and their colleagues came to their conclusions following several types of experiments.

For example, the researchers added human NK cells and IL-2 or IL-12 to cultures of breast-cancer cells with HER2 and coated with trastuzumab antibodies. In response, the NK cells produced a range of substances (known as cytokines and chemokines) known to attract killer T cells to sites of infection. When the experiment was repeated using cancer cells that lacked HER2 (and therefore were not coated with trastuzumab), however, the NK cells produced little of the T-cell-attracting substances.

The researchers also injected IL-12 and trastuzumab-coated mouse-tumor cells into mice and found that it raised the blood levels of the immune-stimulating substances produced by NK cells.

In addition, the researchers analyzed plasma samples from 15 patients with different types of cancer who were participating in a phase-I clinical trial of trastuzumab plus IL-12. The samples showed short-term increases in immune-stimulating substances produced by NK cells, and long-term increases in three patients who responded to the therapy.

“This is a preliminary study and the findings must be verified,” Carson says, “but overall, the evidence supports the use of immune-stimulating agents in patients who receive antibody-based drugs such as trastuzumab.”

Recent Entries

Comments are closed.


  • nintendo ds lite download music
  • tujhe yaad na meri aayee mp3 download songs pk
  • download house 8 temporada legendado
  • chicken invaders 4 download free full game
  • sony ericsson w705 games
  • norton antivirus download 90 days trial version
  • main aisa hi hoon songs download pk
  • baixar cd exaltasamba 25 anos
  • free download song chanda ki doli mein
  • free full hd bollywood movie download in hindi
  • download perreame jowell y randy ft wisin y yandel
  • pyar to hona hi tha hindi movie songs free download
  • 3r black cherry download free
  • download like a g6 getter remix
  • tweakui windows xp free download
  • download 8 ball pool multiplayer hack
  • download font thai th niramit
  • 945gct-hm motherboard drivers download
  • corel draw 13 download crack
  • zindagi ek jua mp3 songs free download
  • free download driver printer epson lx 800
  • virtual dj le software download
  • queen we will rock you remix mp3 free download
  • gangnam style official music video 3gp download
  • pokemon gold version free download pc
  • garmin gps 76 download
  • ik junoon video song download
  • download virtual dj home free 7.0.4
  • ek glassy do glassy mp3 download free
  • latest opera download windows 7 free
  • download map pb untuk cs
  • download pc games online uk
  • xem phim dong yi tap cuoi han quoc
  • download game hp nokia n-gage qd gratis
  • download megaman x7 pc free full version
  • corel draw x4 download portugues gratis baixaki
  • check if solaris 10 64 bit
  • windows update activex download
  • download big boi for your sorrows
  • kleerup until we bleed mp3 download
  • download videos youtube 3gp format
  • download cd rock nacional anos 80 90
  • download dragon ball z movie 8 broly legendary super saiyan
  • visual c 2008 express edition offline download
  • download software samsung yp-t7j
  • fifa 08 free download pc full version
  • download k-9 movie free
  • .net2.0 software free download
  • download music last fm xbox
  • baixar livro a ultima musica em pdf
  • minolta qms magicolor 2300dl driver download
  • yugioh ́5d para nintendo ds download
  • virtual dj download 5.2 free
  • how to download from youtube
  • download corel draw x4 completo portugues free
  • avast v4.8 download
  • wwe impact v3 downloadable content
  • game ft tyler creator martians vs goblins free download
  • vlc .9 download mac
  • skype nokia n97 mini free download
  • download keyshia cole woman to woman deluxe zip
  • driver hp laserjet 1010 windows 7
  • download blackberry os 7.1 for curve 8520
  • corel draw x5 free download full version with keygen
  • apple store 10 billion download
  • world war z download ebook
  • game.co.uk downloads mac
  • xl hate yourself mp3 download
  • hp officejet 6500 wireless download software
  • google sketchup free download pc
  • download chelsea smile kc blitz remix
  • free download hindi movie love aaj kal video songs
  • download cars tm nation forever
  • sony vegas movie studio platinum 9 free download
  • l's theme song b download
  • download power dvd player for windows xp
  • download google maps for android apk
  • download de filmes gratis avi
  • flash mx download completo portugues serial
  • mortal kombat 9 downloadable characters release date
  • 1920 evil returns aye khuda mp3 songs free download
  • sony psp emulator pc free download
  • windows xp sp3 download completo portugues gratis iso
  • 3 bachelors mp3 songs free download
  • rockstar games gta 4 download pc
  • windows live messenger download for winxp
  • how to download video from jw player for mac
  • 30 minutes less download link
  • dr. house download all seasons
  • how to download wp database
  • download youtube 2 mp3 converter free
  • no download itunes gift card generator
  • gta samp download 0.2x
  • animated themes for nokia 5310 xpressmusic free download
  • download b13 ultimatum movie
  • qb pdf converter download
  • how to download music onto your htc wildfire s
  • um beijo luan santana download busca mp3
  • top radio zu download iunie 2011
  • sap fico certification material free download
  • download fifa 09 game for pc
  • gta iv game free download for mobile
  • download game kung fu nguoi que
  • motogp 2 game free download for pc
  • alone - i.n blue mp3 download
  • fb password hacker free download-mediafire
  • dd-wrt download v24 sp2
  • jailbreak iphone 3g free download
  • how to download dd-214
  • hd writer ae 1.0 download free
  • go launcher ex theme xperia free download
  • download accelerator plus 8.7.0.5 full version free download
  • download crack megaman x8 pc
  • dota maphack 1.26a download
  • audi a3 repair manual download
  • download mp3 cutter java
  • spss download gratis
  • capital t - u be gone mp3 download
  • windows xp backup utility download free
  • 3gp to wmv video converter free download
  • ms office 2007 free download full version for windows xp
  • download break up ke baad song
  • free download 32 bit itunes windows 7
  • pspgodownloadcenter.com review
  • usher dj falling in love mp3 song download
  • download wwe cm punk new theme song 2011
  • download mustek dv4000 driver
  • download mp3 song aye mere watan ke logo
  • download google earth for free 2010 latest version
  • download itunes app for android
  • download gratis do navegador internet explorer 8
  • download filme glee live 3d legendado
  • download fifa 13 demo for pc origin
  • download grey's anatomy 8a temporada legendado
  • how do you download songs on a blackberry curve
  • nicky asu feat bobby pe cine iubesc download free
  • mp3 download app for galaxy s3
  • kc and jojo all my life free music download
  • php code generator free download full version
  • download kesha cannibal zip
  • download hack mii installer v0.5
  • mm karavani telugu songs download
  • written stars mp3 download free tinie
  • avaya ip office manager download software
  • ek niranjan songs download mp3
  • pinnacle hollywood fx volume 3 free download
  • p90x workout guide download
  • download 143 ray j bobby brackins
  • download songs of nsync
  • dedication 4 free mp3 download
  • download here am bryan adams mp3
  • flight radar 24 download free
  • 50 cent - ok you' are right download mp3
  • free download song jhonka hawa ka aaj bhi
  • woh lamhe mp3 free download songs
  • dr dre feat eminem need doctor free mp3 download
  • age empires 3 full version free download windows 7
  • best resume format download ms word
  • download facebook chat for nokia 2690
  • nokia c3 black list software free download
  • download theme blackberry 8520 curve free
  • ko tamil movie songs free download zip
  • ie9 download 64 bit vista
  • gta vice city game free download full version pc cnet
  • download free music htc wildfire s
  • how to download psp games for free full version
  • download map dota allstars v6.64
  • download full version adobe acrobat reader x
  • mozilla firefox download for mac os x 10.4.11
  • ios 6 itunes match download individual songs
  • am legend movie download mp4
  • vr holden commodore workshop manual download
  • she so high above me download mp3
  • baixar filme a era do gelo 4 dublado avi
  • ad-aware 2008 no connection to download server
  • descarga de videos de youtube gratis online
  • download entire website linux
  • laserjet 6l download driver
  • o diario de tati o filme download
  • hp officejet pro 8500 driver download windows xp
  • canon rebel xs driver download
  • songs.pk english songs mp3 free download akon
  • download twilight saga breaking dawn part 2 gratis
  • uc browser cloud download for nokia c2-01
  • fifa 11 download game free pc
  • iu new album download
  • download a origem legendado avi
  • free download football manager 2013
  • free download yaad piya ki aane lagi song
  • free download audi a4 repair manual
  • esto es lo que soy free download
  • cd will not import into itunes
  • download quick boot -v2.1
  • download web browser windows 98
  • fast can download 1gb file
  • how do you download music from itunes to iphone 4
  • meek mill rick ross ima boss mp3 download
  • ps2 games free download iso
  • download java compiler for mac
  • download blackberry software update bold 9000
  • adobe flash player free download for samsung galaxy s2
  • ver y descargar peliculas gratis en español 1 link
  • download adobe flash player 10 for linux
  • microsoft security essentials update download 64 bit
  • free mp3 download got your back t.i keri hilson
  • resident evil 6 download pc free
  • richard muller uz download mp3
  • turning 30 movie download dvd rip
  • download do internet explorer 8
  • download song sanu ek pal chain na aave mp3
  • ek deewana tha movie mp3 download
  • download windows 98 virtual machine vmware
  • herb black eh king download
  • download beautiful free fonts
  • free download bootable windows xp sp2
  • free download pari hoon main by sunita rao
  • jab tak hai jaan mp3 songs free download for mobile
  • free download fool you cee lo green
  • download brian lara international cricket 2007 full version pc
  • free pc educational games for kids download
  • c visual studio express download
  • download games xperia x10i free
  • download virtual dj setup
  • directx 11 download windows 7 32 bit
  • download need love ll cool j
  • redsnow 0.9. 8b4 download
  • uk top 100 music download
  • download xp home sp3
  • daughtry - tennessee line download mp3
  • download windows 98 plus themes windows xp
  • adobe photoshop mac download cracked
  • free download mobile games for nokia c2-01
  • yu-gi-oh download game
  • download hd writer ae 1.5
  • download clip bao cong xu ton ngo khong full
  • how do i download youtube videos to my blackberry playbook
  • download game dynasty warriors 7
  • download do filme amor alem da vida legendado
  • microsoft windows xp download games
  • lak 28 kudi da 47 weight kudi da mp3 free download
  • download de grand chase 3 season
  • ramanichandran tamil novels pdf free download
  • java 1.3 free download for windows xp
  • iphone 2g 3.9 bootloader download
  • free full movies online to watch now without downloading
  • download phim tan loc dinh ky - truong ve kien
  • final fantasy 13 free music download
  • rarbg software free download
  • a to z video converter download
  • virtual ti-83 plus rom download
  • download driver sato cx series
  • download musica dragon ball z budokai 3
  • patch v23 do cs 1.6 non steam download chomikuj
  • rc build 7100 download
  • garena client free download latest version
  • death note l's theme mp3 free download
  • download e72 games free
  • nba live 2003 demo free download
  • om shanti om hindi mp3 songs download free
  • lil wayne tha carter 3 album download zip
  • download lagu b'z don't wanna lie
  • avira antivirus update free download 2012
  • o universo history channel 2 temporada download
  • usb bootable xp software download
  • ajab prem ki ghazab kahani mp4 video songs free download
  • download tu dien lac viet 2008 mien phi
  • download hair sims 3 free mac
  • hp usb disk storage format tool download win 7
  • u2 live in chicago 2005 for download
  • corel draw x4 download free crack
  • free download opera for nokia c2-03
  • itunes 9.2 free download mac
  • pokemon season 15 free download
  • dil pardesi ho gaya film songs download
  • download hp laserjet 5n driver
  • download kk songs collection
  • rs agarwal download verbal nonverbal reasoning
  • canon eos 7d manual free download
  • download phan mem diet virus bkav 2011 mien phi
  • free download sql interview questions and answers pdf
  • manual sony h9 download
  • jailbreak ps3 firmware 3.56 download
  • microsoft sql server 2008 r2 service pack 2 download
  • download ps i love you movie in hindi
  • ld assistant free download
  • download games psp iso free
  • redsnow 0.9.6b1 download for windows
  • 50 cent feat. nate dogg - 21 questions download mp3
  • download lagu cn blue album first step
  • mp navigator download windows vista
  • windows 98 2nd edition update
  • youtube video mp3 converter free download mac
  • free download movie maker windows 7 starter
  • download four letter word by diggy simmons
  • windows live movie maker 2012 beta download
  • kolaveri di download 3gp hd
  • sd gundam online download malaysia
  • ptcl evdo drivers download
  • download videos from youtube online for free
  • 20 20 cabinet design software free download
  • download jlc internet tv 2010
  • g download xcode
  • mp3 player free downloads kids
  • vr-networld update 4 download
  • download nero 8 serial download
  • os 4.3.5 ipsw direct download links
  • xem phim song hung ky hiep tvb
  • ek dantaya mp3 song free download
  • ra one criminal full video songs free download mp4
  • cd luan santana ao vivo mp3 download
  • song lyrics n dubz morning star
  • download auto joiner 4.9.1
  • free download mere brother ki dulhan ringtones
  • play free online hidden object games no download required
  • can download windows xp mode
  • download pdf tutorial for photoshop